Dr. Gayathri built Sambhav Foundation with a vision to enable livelihoods and enhance the quality of life of vulnerable communities through Education, Employability, and Entrepreneurship. Her mission is to touch millions of lives, empowering youth, men, and women to earn a decent living and become micro-entrepreneurs.

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She has been extensively involved in policy issues and community mobilizations relating to labour and livelihoods, leading to recognition and accolades across the globe. Gayathri was cited as one of the Top 50 Women in Business by Business Today in 2017 and recognized as Entrepreneur of the Year (Social Business Category) by Forbes India in 2018. She is also a recipient of NITI Aayog's Women Transforming India Award (2021) and has been a TED speaker several times. Between 1999 and 2007, Gayathri worked for the International Labour Organization (ILO), a United Nations agency. She holds a Doctorate in Development Studies and has authored 30 publications in the areas of labour, employment, and gender issues.

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